Movie 2.
Smad6 mutant embryonic liver has disorganized vascular tree lacking some large vessels. 3D rotational view of light-sheet microscopy on whole E16.5 Smad6iΔ/iΔ liver stained for Lyve-1 (magenta) and αSMA (cyan). Gamma was increased to 1.5 to visualize αSMA staining on peripheral branches. Scale bar, 800μm.
Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development
Development 2023. 150:None-None; doi: 10.1242/dev.201811