Movie 1.

Representative DSP-GFP iPSC-Derived Aggregates Undergoing Inner Ear. Organoid Induction. A 24-hour time-lapse recording of three organoids between days 11-12. Z-stacked images were taken every hour. Note the evaginating vesicle-like structures reminiscent of invaginating otic vesicles in the embryo.

Mapping oto-pharyngeal development in a human inner ear organoid model

Matthew R. Steinhart, Wouter H. van der Valk, Daniel Osorio, Sara A. Serdy, Jingyuan Zhang, Carl Nist-Lund, Jin Kim, Cynthia Moncada-Reid, Liang Sun, Jiyoon Lee, and Karl R. Koehler

Development 2023. 150:None-None; doi: 10.1242/dev.201871