Movie 2.
Disrupted secondary sprouting in a tie1 mutant embryo. Time-lapse recording in the trunk of a Tg(kdrl:EGFP);Tg(lyve1:DsRed) tie1-/- embryo from 37 hpf taken every 30 min by confocal microscopy. Elapsed time (h:min:sec). Lateral view, anterior to the left. In the tie1 mutant, sprouting ECs extend their protrusions but do not migrate dorsally.
Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish
Development 2024. 151:None-None; doi: 10.1242/dev.202269