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Movie 9.

Time lapse light sheet movie of a Wnt5a-/-; Wnt1:Cre;mTmG embryo at E10.5. The field of view is within the apical region of supraorbital mesenchyme near the adjacent lateral ectoderm on the left. Cell membranes are sparsely labelled in green due to mosaicism of the Cre allowing for visualization of filopodia. Filopodial activity is present but not oriented apically or basally and the cell body (dark) moves little in response to the protrusions.

Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion

Nikaya Polsani, Theodora Yung, Evan Thomas, Melissa Phung-Rojas, Isha Gupta, Julie Denker, Kimberly Lau, Xiaotian Feng, Beatriz Ibarra, Sevan Hopyan, and Radhika P. Atit

Development 2024. 151:None-None; doi: 10.1242/dev.202596