Movie 9.
The Clock and Wavefront Self-Organizing model can capture the changes in phase wave width observed in-vivo. The CWS model can be adjusted to incorporate a linear graded modulation of R (k1) instead of a step-wise change to capture the changes in phase wave width observed in-vivo (Fig. 4Q). Wnt waves slow down as they move anteriorly, while Notch waves propagate at the same speed catching up to the Wnt waves and ending up in phase.
The Clock and Wavefront Self-Organizing model recreates the dynamics of mouse somitogenesis in vivo and in vitro
Development 2024. 151:None-None; doi: 10.1242/dev.202606