To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoPlayMuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window. Captions Settings Dialog Beginning of dialog window. Escape will cancel and close the window. Text Color White Black Red Green Blue Yellow Magenta Cyan Transparency Opaque Semi-Opaque Background Color Black White Red Green Blue Yellow Magenta Cyan Transparency Opaque Semi-Transparent Transparent Window Color Black White Red Green Blue Yellow Magenta Cyan Transparency Transparent Semi-Transparent Opaque Font Size 50% 75% 100% 125% 150% 175% 200% 300% 400% Text Edge Style None Raised Depressed Uniform Dropshadow Font Family Proportional Sans-Serif Monospace Sans-Serif Proportional Serif Monospace Serif Casual Script Small Caps Defaults Done Movie 2 Ventricular morphology of the treated zebrafish at week 32, derived from B-mode echocardiography. Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish Yanyi Sun, Qiuyun Wang, Yuehua Fang, Chunfang Wu, Guoping Lu, and Zhenyue Chen Disease Models and Mechanisms 2017. 10:1217-1227; doi: 10.1242/dmm.026781 Download Original Video