To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie 3 Atrioventricular (AV) valve velocity of the wild-type zebrafish at week 32, derived from Doppler echocardiography. Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish Yanyi Sun, Qiuyun Wang, Yuehua Fang, Chunfang Wu, Guoping Lu, and Zhenyue Chen Disease Models and Mechanisms 2017. 10:1217-1227; doi: 10.1242/dmm.026781 Download Original Video