To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Supplemental Movie 4 Three-dimensional reconstruction of an E11.5 PdgfraGFP/+ whole mount embryo staining for endothelial cells (Pecam1, Red) and Pdgfra expression (GFP, green). Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries Haig Aghajanian, Young Kuk Cho, Nicholas W. Rizer, Qiaohong Wang, Li Li, Karl Degenhardt, and Rajan Jain Disease Models and Mechanisms 2017. 10:1101-1108; doi: 10.1242/dmm.029710 Download Original Video