Movie S1
Activation of SK channels in the midst of a caffeine-induced attack aborts the attacks. Tottering mouse implanted with a cannula in the cerebellum shown 15 minutes post intraperitoneal injection of 10 mg/Kg caffeine, and 10 minutes (25 minutes post caffeine injection) post NS309 infusion.
Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2
Disease Models and Mechanisms 2018. 11:None-None; doi: 10.1242/dmm.034181