Movie 2

Contracting heart of a nsh mutant embryo.
Representative frontal view of a mutant heart at 5 dpf. The nsh mutant heart had lost elasticity, beat in a rigid manner and showed increased thickening of the myocardial wall, even without blood flow.

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Yuta Higashikuse, Nishant Mittal, Takuro Arimura, Sung Han Yoon, Mayumi Oda, Hirokazu Enomoto, Ruri Kaneda, Fumiyuki Hattori, Takeshi Suzuki, Atsushi Kawakami, Alexander Gasch, Tetsushi Furukawa, Siegfried Labeit, Keiichi Fukuda, Akinori Kimura, and Shinji Makino

Disease Models and Mechanisms 2019. 12:None-None; doi: 10.1242/dmm.041103

Download Original Video