Movie 2
Contracting heart of a nsh mutant embryo.
Representative frontal view of a mutant heart at 5 dpf. The nsh mutant heart had lost elasticity, beat in a rigid manner and showed increased thickening of the myocardial wall, even without blood flow.
Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients
Disease Models and Mechanisms 2019. 12:None-None; doi: 10.1242/dmm.041103