Movie 2

Video representation of Bmp7ncko mice demonstrating lethargy. Bmp7ctrl (top panel) and Bmp7ncko (bottom panel) mice were placed on the treadmill for 5 mins after acclimatization to run. The Bmp7ctrl mice demonstrated no signs of inactivity and rest, however the Bmp7ncko mice demonstrate short period of running followed by long periods of rest.

Neural crest-specific loss of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction and disordered breathing, modeling obstructive sleep apnea

Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, and Daniel Graf

Disease Models and Mechanisms 2021. 14:None-None; doi: 10.1242/dmm.047738