Movie 2

Video representation of Bmp7^ncko mice demonstrating lethargy. Bmp7^ctrl (top panel) and Bmp7^ncko (bottom panel) mice were placed on the treadmill for 5 mins after acclimatization to run. The Bmp7^ctrl mice demonstrated no signs of inactivity and rest, however the Bmp7^ncko mice demonstrate short period of running followed by long periods of rest.

Neural crest-specific loss of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction and disordered breathing, modeling obstructive sleep apnea

Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, and Daniel Graf

Disease Models and Mechanisms 2021. 14:None-None; doi: 10.1242/dmm.047738

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