Movie 3.

Markedly abnormal swimming behaviour in gba-/- with typical “corkscrew” swimming pattern. All adults placed into a novel tank swim in circular motions with balance and buoyancy defects. These increase with frequency and duration at end stage until they need to be culled for humane reasons.

Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency

Marcus Keatinge, Matthew E. Gegg, Lisa Watson, Heather Mortiboys, Nan Li, Mark Dunning, Deepak Ailani, Hai Bui, Astrid van Rens, Dirk J. Lefeber, Anthony H. V. Schapira, Ryan B. MacDonald, and Oliver Bandmann

Disease Models and Mechanisms 2023. 16:None-None; doi: 10.1242/dmm.049954