Movie 1.
Predicted AlphaFold structure of ROCK1. The AlphaFold (Jumper et al., 2021) predicted structure of full-length mouse ROCK1 (AF-P70335-F1). Kinase domain indicated in light green, pleckstrin homology domain indicated in dark blue, cysteine-rich domain indicated in light blue, rho-binding domain indicated in dark green, Asp1113 indicated in red. Image rendered and annotated with UCSF Chimera (Pettersen et al., 2004).
Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice
Disease Models and Mechanisms 2024. 17:None-None; doi: 10.1242/dmm.050631