Movie 7

A very large cell that forms waves on the substrate-attached membrane and responds to gradients of chemoattractant. The cell recorded similar to Movie 2, forms propagating waves of activated Ras (red) on the substrate-attached membrane and simultaneously responds to changing directions of chemoattractant. Frame-to-frame interval 2.16 s.

Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells

Markus Lange, Jana Prassler, Mary Ecke, Annette Müller-Taubenberger, and Günther Gerisch

J Cell Sci 2016. 129:3462-3472; doi: 10.1242/jcs.191148