Movie 1

Knockdown of ADAM12 increases focal adhesion lifetime in Hs578Ts cells.
Time-lapse confocal image sequences acquired with a 60x objective of an Hs578T shCtrl cell (left) or shA12.4 cell (right) transfected with paxillin-mCherry. This image sequence includes the cells depicted in Figure 6G. Images were captured at 1 min intervals for 60 min. Playback is 6 frames / sec. Scale bar, 10μm.

ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions

Mark A. Eckert, Miguel Santiago-Medina, Thinzar M. Lwin, Jihoon Kim, Sara A. Courtneidge, and Jing Yang

J Cell Sci 2017. 130:2036-2048; doi: 10.1242/jcs.198200