Movie 2
pH fluctuations upon high frequency stimulation
Neurons were imaged by time-lapse fluorescence microscopy, at λex = 405 nm (1 image/2.58 s, total time: 350 s, movie played at 29 frames/s) under high frequency electrical stimulation (1200 AP, 10 Hz).
Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses
J Cell Sci 2017. 130:1435-1449; doi: 10.1242/jcs.198564