Movie 6

Loss of centrosome-spindle coupling induces centrosome mis-segregation.
Mitotic cell in wt tissue expressing Tub:GFP (green) and Spd-2:RFP (red). Laser assisted severing of the centrosome-spindle connection (red arrows) results in centrosome missegregation. Yellow arrows: centrosome attached to the spindle, white arrows: centrosome which mis-segregates.

Sequential activities of Dynein, Mud and Asp in centrosome–spindle coupling maintain centrosome number upon mitosis

Floris Bosveld, Anna Ainslie, and Yohanns Bellaïche

J Cell Sci 2017. 130:3557-3567; doi: 10.1242/jcs.201350