Movie 3
EGFR-GFP moves from the plasma membrane to intracellular punctae after UVB treatment in HeLa cells
HeLa cells transiently transfected with EGFR-GFP were serum-starved overnight, then the medium was replaced with CIM and the cells were treated with UVB (800J/m2). The cells were imaged as in Movie 1, with first frame acquired at 3.5 min after irradiation. Bar:10µm.
Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation
J Cell Sci 2017. 130:2481-2490; doi: 10.1242/jcs.202358