Supplemental Movie 4
10 mM MG132-treated mito-roGFP cells matched to vehicle-treated cells in Supplemental Movie 3 show rapid fission and fusion, with a net retrograde mitochondrial trafficking leading to perinuclear clustering of the mitochondria. Arrows denote cells displaying juxtanuclear mitochondrial rings induced by proteasome inhibition.
A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking
J Cell Sci 2017. 130:3467-3480; doi: 10.1242/jcs.203216