Movie 1

Normal spindle formation and mitotic progression after ASPM KO
SiR-tubulin images were acquired every 3 min with spinning-disc confocal microscopy. Images were acquired with 5 z-sections (separated by 3 μm) and displayed after maximum projection. Time 0 corresponds to the timing of nuclear envelope breakdown. The images of two KOExon1 lines (#4 and #23) and two complete KOC lines (#25 and #27) are presented.

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2

Elsa A. Tungadi, Ami Ito, Tomomi Kiyomitsu, and Gohta Goshima

J Cell Sci 2017. 130:3676-3684; doi: 10.1242/jcs.203703