Movie-S1

A HeLa cell expressing Opn4 and PIP2 sensor (Venus-PH) shows profound PIP2 hydrolysis upon addition of 50 μM 11-cis-retinal. Scale bar 10 mm.

Melanopsin (Opn4) utilizes Gαi and Gβγ as major signal transducers

Dinesh Kankanamge, Kasun Ratnayake, Saroopa Samaradivakara, and Ajith Karunarathne

J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.212910

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