Supplemental Movie 6

Actin dynamics in migrating Ishikawa cells expressing eGFP-tagged FGFR wild type or the activating mutant N550K. Spinning disc confocal microscopy time-lapse sequence of Ishikawa cells co-expressing eGFP-tagged receptor (magenta) with the filamentous actin reporter LifeAct-mCherry (black). Images were acquired every 3 minutes for 3 hours. The video plays back at 10 frames s-1 and is thus accelerated 1800 times.

FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models

Samantha J. Stehbens, Robert J. Ju, Mark N. Adams, Samuel R. Perry, Nikolas K. Haass, David M. Bryant, and Pamela M. Pollock

J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.213678