Movie S1
The SLP-76 SH2 domain regulates TCR-induced SLP-76 microcluster centralization and persistence (WT SLP-76 movie). SLP-76 deficient Jurkat T cells (J14 cells) were transiently transfected with an expression vector for a wild-type (WT) SLP-76.YFP chimera of human origin.
ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters
J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.215517