Movie S7
The ADAP-120 and ADAP-130 isoforms both enter TCR-induced SLP-76 microclusters and lamellipodia (TRT control movie). J14.SY cells were transiently transfected with a 3xFlag.TRT control for the ADAP expression vectors seen in movies S8-S9. TRT protein is shown in the left panel and in red in the merge, SLP-76 in the middle panel and in green in the merge.
ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters
J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.215517