Movie S2

Flotillin 2 and MT1-MMP are colocalized at invadopodia
MDA-MB-231 cells that co-express flotillin 2-mCherry and MT1-MMP-GFP were imaged on fluorescent gelatin using confocal microscopy; 1 frame/5 seconds. Arrows indicate MT1-MMT and flotillin 2-containing vesicles present throughout the imaging period (yellow) or disappearing (white) probably due to exocytosis. Scale bar: 5 μm.

MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins

Damien Planchon, Eduardo Rios Morris, Mallory Genest, Franck Comunale, Sophie Vacher, Ivan Bièche, Evgeny V. Denisov, Lubov A. Tashireva, Vladimir M. Perelmuter, Stefan Linder, Philippe Chavrier, Stéphane Bodin, and Cécile Gauthier-Rouvière

J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.218925