Movie S5

Flotillin 2 and RAB7 are colocalized in intracellular vesicles
C2C12F1F2 cells that co-express flotillin 2-mCherry and RAB7-GFP were imaged using confocal microscopy; 1 frame/3 seconds. Flotillin-rich endocytic vesicles forming at dynamic PM ruffles (red arrow) were rapidly enriched in RAB7, a LE marker (green arrow). Scale bar: 2 μm.

MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins

Damien Planchon, Eduardo Rios Morris, Mallory Genest, Franck Comunale, Sophie Vacher, Ivan Bièche, Evgeny V. Denisov, Lubov A. Tashireva, Vladimir M. Perelmuter, Stefan Linder, Philippe Chavrier, Stéphane Bodin, and Cécile Gauthier-Rouvière

J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.218925