Movie S6

Flotillin 2 and RAB5 are colocalized in endocytic vesicles
C2C12F1F2 cells that co-express flotillin 2-mCherry and RAB5-GFP were imaged using confocal microscopy; 1 frame/3 seconds. Yellow arrow indicates flotillin-rich endocytic vesicles forming at dynamic PM ruffles that are RAB5-positive early endosomes and fusing together. Red arrow indicates a flotillin-positive vesicle loosing RAB5 expression. Scale bar: 2 μm.

MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins

Damien Planchon, Eduardo Rios Morris, Mallory Genest, Franck Comunale, Sophie Vacher, Ivan Bièche, Evgeny V. Denisov, Lubov A. Tashireva, Vladimir M. Perelmuter, Stefan Linder, Philippe Chavrier, Stéphane Bodin, and Cécile Gauthier-Rouvière

J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.218925