Movie 1

MCF10A cells stably expressing GFP-DLC3-K725E were pretreated with TGF-β for 7 days, transfected with pmOrange2-C1-Endo RhoB and, on the next day, replated onto collagen-coated coverslips. 24 h later, cells were imaged by TIRF live microscopy. Time in seconds. Scale bar, 2 μm.

DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes

Bettina Noll, David Benz, Yannick Frey, Florian Meyer, Manuel Lauinger, Stephan A. Eisler, Simone Schmid, Peter L. Hordijk, and Monilola A. Olayioye

J Cell Sci 2019. 132:None-None; doi: 10.1242/jcs.223172