Movie 1

Nuclei shrinkage under fluid shear stress. Fluorescent images of nuclei of MDCK cells subjected to shear stress (1.1 dyn/cm2), showing that the nuclear sizes decreased with flow. Nuclei visualized with Hoechst 33342. The images acquired at 2 min per frame for a total recording time of 120 min. Yellow arrow indicates the start of flow and the flow direction.

Shear stress-induced nuclear shrinkage through activation of Piezo1 channels in epithelial cells

Deekshitha Jetta, Philip A. Gottlieb, Deepika Verma, Frederick Sachs, and Susan Z. Hua

J Cell Sci 2019. 132:None-None; doi: 10.1242/jcs.226076