To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie 6 4D intravital imaging of orthotopic xenograft tumor cell from Fig. 5A. MDA-MB-231-FUCCI-mCerulean3-Lifeact7 tumor cell in G1 (red nucleus) extends and retracts an actin-rich (cyan) protrusion. Images were acquired every 3 minutes for 30 minutes. Scale bar 10 μm. Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle Battuya Bayarmagnai, Louisiane Perrin, Kamyar Esmaeili Pourfarhangi, Xavier Graña, Erkan Tüzel, and Bojana Gligorijevic J Cell Sci 2019. 132:None-None; doi: 10.1242/jcs.227116 Download Original Video