Movie 3 (related to Figure 3L)
Dextran-AF555 (Dex555) (red) was internalized by 4 h pulse and 20 h chase into lysosomes of MNT-1 cells overexpressing 2xFYVE-GFP (localized on stage I melanosomes). Then cells were treated for 2 h with DMSO. Movies were taken at a frame rate of 1.4 s and 10 frames are shown.
The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation
J Cell Sci 2019. 132:None-None; doi: 10.1242/jcs.229500