Movie 2

Molecular dynamic simulations of the αVβ3 integrin exposed to unidirectional force. The ectodomain of the αVβ3 integrin (αV is shown in blue and β3 integrin is shown in red) in which a 200 kJ mol^-1 nm^-1 force parallel to the membrane was applied on the βA domain of the head region of the inactive form. Water and ions are omitted for clarity. The integrin Calf-2 and β-tail domains were restrained to mimic the cell membrane (see Methods for more details).