Movie 2

Tumor Cell Diapedesis Extravasation. In vivo imaging of an injected fluorescently-labelled HeLa cervical cancer cell undergoing extravasation through diapedesis. The HeLa cell (cyan) squeezes through the blood vessel (red) wall with minimal vascular restructuring. The HeLa cell transmigrates form the lumen of the blood vessel into surrounding tissue. 3D rendered version on right. SB = 20 μm

Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential

Tyler A. Allen, Dana Asad, Emmanuel Amu, M. Taylor Hensley, Jhon Cores, Adam Vandergriff, Junnan Tang, Phuong-Uyen Dinh, Deliang Shen, Li Qiao, Teng Su, Shiqi Hu, Hongxia Liang, Heather Shive, Erin Harrell, Connor Campbell, Xinxia Peng, Jeffrey A. Yoder, and Ke Cheng

J Cell Sci 2019. 132:None-None; doi: 10.1242/jcs.231563