A Single Cell from a Tumor Cell Cluster Breaking Off and Undergoing Diapedesis. In vivo imaging of an injected fluorescently-labelled HeLa cervical cancer cell breaking off from a cluster and undergoing extravasation through diapedesis. The HeLa cell (cyan) squeezes through the blood vessel (red) wall with minimal vascular restructuring while the rest of the cluster goes on its merry way through the circulation. The HeLa cell transmigrates form the lumen of the blood vessel into surrounding tissue.
3D rendered version on right. SB = 20 μm.