Movie 7

Human Cluster Proliferation Over 96 Hours Following Angiopellosis Extravasation. A cluster of human HeLa tumor cells outside of the blood vessel into an extravascular cavity as a multicellular group. The cell cluster is then imaged (and 3D modeled) once every 24 hours post extravasation to monitor growth over 96 hours. SB = 50 μm.

Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential

Tyler A. Allen, Dana Asad, Emmanuel Amu, M. Taylor Hensley, Jhon Cores, Adam Vandergriff, Junnan Tang, Phuong-Uyen Dinh, Deliang Shen, Li Qiao, Teng Su, Shiqi Hu, Hongxia Liang, Heather Shive, Erin Harrell, Connor Campbell, Xinxia Peng, Jeffrey A. Yoder, and Ke Cheng

J Cell Sci 2019. 132:None-None; doi: 10.1242/jcs.231563