Movie 8

Animation of Single and Clustered Tumor Cells Extravasating through Angiopellosis. This animation illustrates the basic difference in mechanism of angiopellosis cluster and individual cell extravasation. In the cell cluster angiopellosis panel (left), the circulating tumor cell cluster travels through the blood vessel and attaches to the endothelial lining of the vasculature. The membrane projections of endothelial cells then actively cover the tumor cell, prompting the expulsion of the cell into the surrounding tissue. These cell then proliferate as a tumor mass. In the individual cell angiopellosis panel (right), the circulating tumor cell travels through the blood vessel and attaches to the endothelial lining of the vasculature. The membrane projections of endothelial cells then actively cover the tumor cell, prompting the expulsion of the cell into the surrounding tissue. These cell remains dormant and does not proliferate into a tumor mass.