Movie 2

Simulation corresponding to panels A and B of Fig. 8. Cross section through the growth cone and distal axon is shown on top; individual filaments are shown below; kymograph of MT (red) and F-actin (blue) motion is indicated on the bottom. Disruption of dynein decreases its forward push. Tension generated in the axon overcomes the forward pull of the growth cone and the axon retracts.

Dynein-mediated microtubule translocation powering neurite outgrowth in chick and Aplysia neurons requires microtubule assembly

Kristi McElmurry, Jessica E. Stone, Donghan Ma, Phillip Lamoureux, Yueyun Zhang, Michelle Steidemann, Lucas Fix, Fang Huang, Kyle E. Miller, and Daniel M. Suter

J Cell Sci 2020. 133:None-None; doi: 10.1242/jcs.232983