Movie 12
The Cdc25B inhibitor, NSC95397, induces anaphase and PBE in Cep55-depleted oocytes. Timelapse imaging of a Cep55-depleted oocyte expressing H2B-RFP (red) and stained with SiR-tubulin dye (green) treated with NSC95397 from 6 h post-GVBD. Time scale is shown in hh:mm. Note that anaphase I and PBE occur by 10 h post-GVBD.
First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation
J Cell Sci 2019. 132:None-None; doi: 10.1242/jcs.233379