Movie 2
DLC1 is needed for endothelial directional migration. Time lapse recording of HUVECs transduced with shControl, shDLC1 3'UTR or shDLC1 #1063 during scratch wound migration. Images were acquired by time-lapse phase-contrast microscopy (NIKON Eclipse Ti) using a 10x dry objective. Frames were taken every 10 min for ~ 16 hours.
DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis
J Cell Sci 2020. 133:None-None; doi: 10.1242/jcs.239947