Movie 6
Targeting PTEN to the cell surface depletes PIP3 and reduces bubbling bleb formation in RD cells. Live-cell imaging of RD cells transfected with Lyn-CFP-FRB, YFP-FKBP-PTEN, and mCherry-AktPH. Rapamycin-induced YFP-FKBP-PTEN translocation inhibits bubbling blebs in RD cells.
PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells
J Cell Sci 2020. 133:None-None; doi: 10.1242/jcs.240325