Movie 12.
PLP2 mediated collective cell migration involves Rac1 activation. Phase-contrast images of migrating PLP2KO cells co-expressing PLP2-mCherry and GFP (left)/ GFP-Rac1DN (middle)/ GFP-Rac1WT (right) respectively. 1 frame/ 15 mins for 12 hrs. Scale bars: 50 μm.
PLP2 drives collective cell migration via ZO-1-mediated cytoskeletal remodeling at the leading edge in human colorectal cancer cells
J Cell Sci 2021. 134:None-None; doi: 10.1242/jcs.253468