Movie 5.
PLP2 depleted cells exhibit slower wound closure. Phase-contrast images of migrating SW480 cells treated with nontargeted (Scr) (left) and PLP2 targeted (right) SiRNA SMARTpool; 1 frame/ 15 mins for 12 hrs. Scale bars: 50 μm.
PLP2 drives collective cell migration via ZO-1-mediated cytoskeletal remodeling at the leading edge in human colorectal cancer cells
J Cell Sci 2021. 134:None-None; doi: 10.1242/jcs.253468