To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie 1. Dynamic podosomes colocalize with traction hot spots. Shown is an example cell from Fig. 2 with surface-projected Lifeact-EGFP (in green) and overlayed in-plane tractions (in magenta). Capturing interval: 5 seconds. Scale bar: 10 μm. Analysis of monocyte cell tractions in 2.5D reveals mesoscale mechanics of podosomes during substrate-indenting cell protrusion Hendrik Schürmann, Fatemeh Abbasi, Antonella Russo, Arne D. Hofemeier, Matthias Brandt, Johannes Roth, Thomas Vogl, and Timo Betz J Cell Sci 2022. 135:None-None; doi: 10.1242/jcs.259042 Download Original Video