Movie 1.
Time-lapse demonstration of nuclear condensate formation and fusion of EYFP-TAZ by live-cell imaging. Live cell spinning disk confocal imaging of ectopically expressed EYFP-TAZ (green) was carried out indicating the formation of spherical condensate structures inside the nucleus (imaged using Hoechst 33342 in blue). Videos document fusion properties of EYFP-TAZ condensates.
TAZ exhibits phase separation properties and interacts with Smad7 and β-catenin to repress skeletal myogenesis
J Cell Sci 2022. 135:None-None; doi: 10.1242/jcs.259097