Movie 1.

Time-lapse movie for sequestration of TDP-43 over-expressing FLAG-TDP-35. Movie related to Fig. 6B. The movie was imaged with 20-min intervals in the EGFP-TDP-43 cell line transfected with FLAG-TDP-35. The imaging began at c.a. 12 hrs after transfection with FLAG-TDP-35. TDP-43 was indicated from the fluorescence of its fused EGFP (green). The live-cell images were obtained by Zeiss Celldiscoverer 7 (Zeiss). Scale bar, 5 μm.

RNA-assisted sequestration of RNA-binding proteins by cytoplasmic inclusions of the C-terminal 35-kDa fragment of TDP-43

Lei-Lei Jiang, Wen-Liang Guan, Jian-Yang Wang, Shu-Xian Zhang, and Hong-Yu Hu

J Cell Sci 2022. 135:None-None; doi: 10.1242/jcs.259380