Movie S5

mRNA of Cox7c-MTS STOP MS2 visualized with MCP-GFP construct and displays low frequency of co-localization with mitochondria in axons. Live-cell imaging of mRNA particles (green) together with mitotracker-marked mitochondria (red) in a motor neuron axon. The red arrow indicates Cox7c-MTS-STOP mRNA particles co-localizes with static mitochondria. Note that moving mRNA puncta are not colocalized with mitochondria. Movie speed is 10 frames per second, at 3 seconds per frame.

Co-transport of the nuclear-encoded Cox7c mRNA with mitochondria along axons occurs through a coding-region-dependent mechanism

Bar Cohen, Topaz Altman, Adi Golani-Armon, Anca F. Savulescu, Amjd Ibraheem, Musa M. Mhlanga, Eran Perlson, and Yoav S. Arava

J Cell Sci 2022. 135:None-None; doi: 10.1242/jcs.259436