To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie 4. Time-lapse imaging of an A375-M2 cell over-expressing (OE) emerin-EGFP, which has been confined down to ∼3 μm. Cells were stained with membrane dye. Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments Sandrine B. Lavenus, Karl W. Vosatka, Alexa P. Caruso, Maria F. Ullo, Ayesha Khan, and Jeremy S. Logue J Cell Sci 2022. 135:None-None; doi: 10.1242/jcs.259493 Download Original Video