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Movie 4.

PIHes-1/Bulk cancer cells possess the ability to switch back to NIHes-1 expressing state. Time-lapse imaging reveals that PIHes-1 cancer cells can switch back to NIHes-1 expressing state and later transit to NDHes-1 expressing state in vitro.

HES1 promoter activation dynamics reveal the plasticity, stemness and heterogeneity in neuroblastoma cancer stem cells

Paul Ann Riya, Budhaditya Basu, Suresh Surya, Surendran Parvathy, Soundararajan Lalitha, Nair Pradeep Jyothi, Vadakkath Meera, Vishnu Sunil Jaikumar, Padmanabhan Sunitha, Afzal Shahina, Rashmi Sukumaran, Achuthsankar Sukumaran Nair, Sivadasan Bindu Dhanesh, John Jiffy, Shijulal Nelson-Sati, Tessy Thomas Maliekal, Ani Venmanad Das, and Jackson James

J Cell Sci 2022. 135:None-None; doi: 10.1242/jcs.260157