Movie 4.
PIHes-1/Bulk cancer cells possess the ability to switch back to NIHes-1 expressing state. Time-lapse imaging reveals that PIHes-1 cancer cells can switch back to NIHes-1 expressing state and later transit to NDHes-1 expressing state in vitro.
HES1 promoter activation dynamics reveal the plasticity, stemness and heterogeneity in neuroblastoma cancer stem cells
J Cell Sci 2022. 135:None-None; doi: 10.1242/jcs.260157