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Movie 1.

RGC growth cone expressing mNG-TOCA-1 and GAP43-RFP, showing TOCA-1 recruitment to filopodia, lamellipodia and inwardly-moving puncta. 4 minute video acquired at 2 s per frame, replayed at 20 frames per second.

Filopodial protrusion driven by density-dependent Ena–TOCA-1 interactions

Thomas C. A. Blake, Helen M. Fox, Vasja Urbančič, Roshan Ravishankar, Adam Wolowczyk, Edward S. Allgeyer, Julia Mason, Gaudenz Danuser, and Jennifer L. Gallop

J Cell Sci 2024. 137:None-None; doi: 10.1242/jcs.261057

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