Movie 2.

Influence of vesicle reversal events on cargo transport. The movie shows the evolution of the simulation system in which initially both side-stepping and reversals of vesicle cargo are disallowed. This leads to a jammed configuration with zero net current at around 19 seconds as the vesicles cannot circumvent obstacles by side-stepping on to a neighbouring microtubule track or reverse their direction of motion. This point on, vesicles are allowed to reverse their direction of motion but not side-step on to a neighbouring microtubule track on encountering an obstacle. Transport is restored in the system.

Transport of synaptic vesicles is modulated by vesicular reversals and stationary cargo clusters

Amruta Vasudevan, Reshma Maiya, Keertana Venkatesh, Vinod Kumar, Parul Sood, Kausalya Murthy, Sandhya P. Koushika, and Gautam I. Menon

J Cell Sci 2023. 136:None-None; doi: 10.1242/jcs.261223